| The N CoR HDAC 3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS 2 . ^^^ We report here that GPS 2 , a protein involved in intracellular signaling , is an integral subunit of the N CoR HDAC 3 complex . ^^^ GPS 2 and TBL 1 , another component of the N CoR HDAC 3 complex , interact cooperatively with repression domain 1 of N CoR to form a heterotrimeric structure and are indirectly linked to HDAC 3 via an extended N CoR SANT domain that also activates latent HDAC 3 activity . ^^^ More importantly , we show here that the N CoR HDAC 3 complex inhibits JNK activation through the associated GPS 2 subunit and thus could potentially provide an alternative mechanism for hormone mediated antagonism of AP 1 function . . ^^^ |