| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| Significant antithrombic effect was exhibited by HD 1 , HD 2 , HD 3 , and HD 4 which decreased progressively . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| However , HDAC 4 and HDAC 5 associate with HDAC 3 in vivo . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| Furthermore , HDAC 10 interacts with HDAC 3 but not with HDAC 4 or HDAC 6 . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| The orphan nuclear receptor TR 2 interacts directly with histone deacetylase HDAC 3 and HDAC 4 . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.70882087 |
| Loss of this interaction allows HDAC 4 and HDAC 5 to translocate to the nucleus , interact with HDAC 3 , and repress gene expression . 0.70882087^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| In contrast , two other lines , HD 3 and HD 4 , differentiate to fluid transporting enterocytic cells with functional brush borders and exhibit autocrine negative growth response to TGF beta 1 . ^^^ HI 1 cells synthesized as much TGF beta 1 mRNA as HD 3 and HD 4 cells , yet they responded to exogenous TGF beta 1 with less growth inhibition , suggesting some impairment in their response to TGF beta 1 . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| Notably , like clozapine , the affinity of S 16924 for hD 2 and hD 3 receptors was modest , and it showed 5 fold higher affinity for hD 4 receptors . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| L 745 , 870 similarly showed selectivity for hD 4 ( 2 . 5 nM ) vs . hD 2 ( 905 nM ) and hD 3 ( > 3000 nM ) receptors . ^^^ In contrast , raclopride displayed low affinity at hD 4 ( > 3000 nM ) vs . hD 2 ( 1 . 1 nM ) and hD 3 receptors ( 1 . 4 nM ) . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| D 2 sites ( labeled by [ 125I ] iodosulpride ) was ( + ) S 14297 ( 61 ) approximately GR 103 , 691 ( 60 ) > U 99194 ( 14 ) > nafadotride ( 9 ) approximately ( + ) UH 232 ( 8 ) approximately ( + ) AJ 76 ( 6 ) > haloperidol ( 0 . 2 ) . ( + ) S 14297 and GR 103 , 691 also showed greater than 100 fold selectivity at dopamine hD 3 vs . hD 4 and hD 1 sites . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| After further optimisation the best compound identified was 13 which has high affinity for hD 4 ( 5 . 2 nM ) and > 300 fold selectivity for hD 4 receptors over hD 2 and hD 3 receptors . . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| The present study determined its affinity and agonist efficacy at recombinant human ( h ) dopamine hD 2 , hD 3 and hD 4 and serotonin ( 5 HT ) h 5 HT1A , h 5 HT1B and h 5 HT1D receptors . ^^^ Roxindole exhibited high affinity at hD 3 as well as at hD 2 ( short isoform ) and hD 4 ( 4 repeat isoform ) receptors ( pKi values 8 . 93 , 8 . 55 and 8 . 23 , respectively ) . ^^^ In [ 35S ] GTPgammaS binding experiments , roxindole was > 20 fold more potent in stimulating [ 35S ] GTPgammaS binding at hD 3 than at hD 2 or hD 4 receptors ( pEC 50 = 9 . 23 vs . 7 . 88 and 7 . 69 ) . ^^^ However , whereas roxindole exhibited partial agonist activity at hD 3 and hD 4 sites ( Emax = 30 . 0 % and 35 . 1 % , respectively , relative to dopamine = 100 % ) , it only weakly activated hD 2 receptors ( Emax = 10 . 5 % ) . ^^^ In comparison , the dopamine receptor agonist , ( ) quinpirole , acted as a partial agonist at hD 3 and hD 4 sites ( Emax = 67 . 4 % and 66 . 3 % , respectively ) but surpassed the efficacy of dopamine at hD 2 receptors ( Emax = 132 % ) . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| This study characterized pharmacologically the functional responses to agonists at human dopamine D 2 ( long ) ( hD 2 ) , D 3 ( hD 3 ) and D4 . 4 ( hD 4 ) receptors separately expressed in cloned cells using the cytosensor microphysiometer . ^^^ Dopaminergic receptor agonists caused increases in extracellular acidification rate in adherent Chinese hamster ovary ( CHO ) clones expressing hD 2 , hD 3 or hD 4 receptors . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| The aim of the present study was to characterize functional responses to ropinirole , its major metabolites in man ( SKF 104557 ( 4 [ 2 ( propylamino ) ethyl ] 2 ( 3H ) indolone ) , SKF 97930 ( 4 carboxy 2 ( 3H ) indolone ) ) and other dopamine receptor agonists at human dopamine D 2 ( long ) ( hD 2 ) , D 3 ( hD 3 ) and D4 . 4 ( hD 4 ) receptors separately expressed in Chinese hamster ovary cells using microphysiometry . 2 . ^^^ The pEC50s of ropinirole at hD 2 , hD 3 and hD 4 receptors were 7 . 4 , 8 . 4 and 6 . 8 , respectively . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| To date , six HDACs have been identified in mammalian cells : the yeast RPD 3 homologs HDAC 1 , 2 , and 3 and the yeast HDA 1 homologs HDAC 4 , 5 , and 6 . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| Different class 2 HDACs reside in the cell nucleus in stable and autonomous complexes with enzymatic activity , but the enzymatic activities associated with HDAC 7 and HDAC 4 rely on shared cofactors , including HDAC 3 and SMRT / N CoR . . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the catalytic domain of HDAC 4 interacts with HDAC 3 via the transcriptional corepressor N CoR / SMRT . ^^^ All experimental conditions leading to the suppression of HDAC 4 binding to SMRT / N CoR and to HDAC 3 result in the loss of enzymatic activity associated with HDAC 4 . ^^^ In vitro reconstitution experiments indicate that HDAC 4 and other class 2 HDACs are inactive in the context of the SMRT / N CoR HDAC 3 complex and do not contribute to its enzymatic activity . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| In the present study , we investigated whether class 1 and class 2 HDACs interact with GATA 1 to regulate its function and indeed , GATA 1 is directly associated with HDAC 3 , HDAC 4 and HDAC 5 . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| To understand the physiological functions of HDACs , we characterized six different Drosophila HDACs , including Rpd 3 , HDAC 3 , HDAC 4 , HDAC 6 S , HDAC 6 L , and Sir 2 , by developmental expression pattern , transcriptional profiles of target genes , and sensitivity to HDAC inhibitors . ^^^ |
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| Interacting proteins: P56524 and O15379 |
Pubmed |
SVM Score :0.0 |
| Analysis of the predicted amino acid sequence of HDAC A revealed an open reading frame of 967 amino acids containing two domains : a NH 2 terminal domain with no homology to known proteins and a COOH terminal domain with homology to known histone deacetylases ( 42 % similarity to RPD 3 , 60 % similarity to HDA 1 ) . ^^^ |
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