| Interacting proteins: P37231 and O15379 |
Pubmed |
SVM Score :0.0 |
| Regulation of nuclear translocation of HDAC 3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator activated receptor gamma function . ^^^ |
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| Interacting proteins: P37231 and O15379 |
Pubmed |
SVM Score :0.0 |
| PPARgamma and RB were shown to coimmunoprecipitate , and this PPARgamma RB complex also contains the histone deacetylase HDAC 3 , thereby attenuating PPARgamma ' s capacity to drive gene expression and adipocyte differentiation . ^^^ Dissociation of the PPARgamma RB HDAC 3 complex by RB phosphorylation or by inhibition of HDAC activity stimulates adipocyte differentiation . ^^^ These observations underscore an important function of both RB and HDAC 3 in fine tuning PPARgamma activity and adipocyte differentiation . . ^^^ |
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| Interacting proteins: P37231 and O15379 |
Pubmed |
SVM Score :0.0 |
| Through the use of HDAC inhibitors and coimmunoprecipitations , we furthermore demonstrate that the effects of RB on PPARgamma mediated control of the cell cycle and apoptosis depend on the recruitment of histone deacetylase 3 ( HDAC 3 ) to PPARgamma . ^^^ In combination , these data hence demonstrate that the effects of PPARgamma on cell proliferation and apoptosis are dependent on the presence of an RB HDAC 3 complex . . ^^^ |
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| Interacting proteins: P37231 and O15379 |
Pubmed |
SVM Score :0.0 |
| The interaction between PPARgamma and RB decreases the transcriptional activity of PPARgamma through recruitment of the histone deacetylase HDAC 3 . ^^^ |
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| Interacting proteins: P37231 and O15379 |
Pubmed |
SVM Score :0.0 |
| The initial step of this pathway involves ligand dependent SUMOylation of the PPAR gamma ligand binding domain , which targets PPAR gamma to nuclear receptor corepressor ( NCoR ) histone deacetylase 3 ( HDAC 3 ) complexes on inflammatory gene promoters . ^^^ |
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| Interacting proteins: P37231 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
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