| Interacting proteins: O15379 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and P25963 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15379 and P25963 |
Pubmed |
SVM Score :0.0 |
| Deacetylation of RelA by HDAC 3 thus acts as an intranuclear molecular switch that both controls the duration of the NF kappaB transcriptional response and contributes to the replenishment of the depleted cytoplasmic pool of latent NF kappaB IkappaBalpha complexes . . ^^^ |
|
| Interacting proteins: O15379 and P25963 |
Pubmed |
SVM Score :0.0 |
| This selective action of HDAC 3 promotes IkappaBalpha binding and rapid CRM 1 dependent nuclear export of the deacetylated NF kappaB complex , which terminates the NF kappaB response and replenishes the cytoplasmic pool of latent NF kappaB / IkappaBalpha complexes . ^^^ |
|
| Interacting proteins: O15379 and P25963 |
Pubmed |
SVM Score :0.0 |
| Cytoplasmic IkappaBalpha increases NF kappaB independent transcription through binding to histone deacetylase ( HDAC ) 1 and HDAC 3 . ^^^ We show here that IkappaBalpha enhances the transactivation potential of several homeodomain containing proteins such as HOXB 7 and Pit 1 through a NF kappaB independent association with histone deacetylase ( HDAC ) 1 and HDAC 3 but not with HDAC 2 , 4 , 5 , and 6 . ^^^ Immunofluorescence experiments demonstrated further that IkappaBalpha acts by partially redirecting HDAC 3 to the cytoplasm . ^^^ Our results support the hypothesis that the NF kappaB inhibitor IkappaBalpha regulates the transcriptional activity of homeodomain containing proteins positively through cytoplasmic sequestration of HDAC 1 and HDAC 3 , a mechanism that would assign a new and unexpected role to IkappaBalpha . . ^^^ |
|
| Interacting proteins: O15379 and P25963 |
Pubmed |
SVM Score :0.0 |
| Regulation of nuclear translocation of HDAC 3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator activated receptor gamma function . ^^^ HDAC 3 is associated with IkappaBalpha in the cytoplasm . ^^^ After IkappaBalpha degradation in response to TNF alpha , HDAC 3 is subject to nuclear translocation , leading to an increase in HDAC 3 activity in the nucleus . ^^^ Knock out of IkappaBalpha , but not p 65 or p 50 , leads to disappearance of HDAC 3 in the cytoplasm , which is associated with HDAC 3 enrichment in the nucleus . ^^^ Rather , these results suggest that IkappaBalpha dependent nuclear translocation of HDAC 3 is responsible for PPARgamma inhibition by TNF alpha . . ^^^ |
|