| Consistent with our earlier observation that TFII 1 family proteins also interact with PIASxbeta , a member of the E 3 ligase family involved in the small ubiquitin like modifier ( SUMO ) pathway , we show further that PIASxbeta physically and functionally interacts with HDAC 3 and relieves the transcriptional repression exerted by HDAC 3 upon TFII 1 mediated gene activation . 0.53479341^^^ |