| Interacting proteins: O60907 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60907 and O15379 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60907 and O15379 |
Pubmed |
SVM Score :0.0 |
| A core SMRT corepressor complex containing HDAC 3 and TBL 1 , a WD 40 repeat protein linked to deafness . ^^^ In vivo , TBL 1 is bridged to HDAC 3 through SMRT and can potentiate repression by TR . ^^^ |
|
| Interacting proteins: O60907 and O15379 |
Pubmed |
SVM Score :0.0 |
| Using a combination of conventional and immunoaffinity chromatography , we have successfully isolated a SMRT complex and identified histone deacetylase 3 ( HDAC 3 ) and transducin ( beta ) like 1 ( TBL 1 ) , a WD 40 repeat containing protein , as the subunits of the purified SMRT complex . ^^^ |
|
| Interacting proteins: O60907 and O15379 |
Pubmed |
SVM Score :0.0 |
| GPS 2 and TBL 1 , another component of the N CoR HDAC 3 complex , interact cooperatively with repression domain 1 of N CoR to form a heterotrimeric structure and are indirectly linked to HDAC 3 via an extended N CoR SANT domain that also activates latent HDAC 3 activity . ^^^ |
|
| Interacting proteins: O60907 and O15379 |
Pubmed |
SVM Score :0.0 |
| Purification and functional characterization of the human N CoR complex : the roles of HDAC 3 , TBL 1 and TBLR 1 . ^^^ Corepressors N CoR and SMRT participate in diverse repression pathways and exist in large protein complexes including HDAC 3 , TBL 1 and TBLR 1 . ^^^ By using specific small interference RNAs ( siRNAs ) , we demonstrate that HDAC 3 is essential , whereas TBL 1 and TBLR 1 are functionally redundant but essential for repression by unliganded thyroid hormone receptor . ^^^ |
|
| Interacting proteins: O60907 and O15379 |
Pubmed |
SVM Score :0.0 |
| Here we show that endogenous N CoR , TBL 1 , and histone deacetylase 3 ( HDAC 3 ) , but not HDAC 1 , 2 , or 4 , are recruited to a stably integrated reporter gene repressed by unliganded TR as well as the orphan receptor RevErb . ^^^ |
|
| Interacting proteins: O60907 and O15379 |
Pubmed |
SVM Score :0.0 |
| Promoter bound OHT complexed ERa coordinately recruited the components of a multiprotein complex containing the corepressor NCoR , histone deacetylase 3 ( HDAC 3 ) , and a WD 40 repeat protein TBL 1 . ^^^ |
|